Development of a new optical device and its feasibility in prostate cancer detection.
Title | Development of a new optical device and its feasibility in prostate cancer detection. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Panteliou, S. D., Tzortzis V., Anagnostopoulos G. T., Sunaric M. M., Sarris J., Hatzimouratidis K., & Hatzichristou D. |
Journal | Urol Int |
Volume | 89 |
Issue | 3 |
Pagination | 290-5 |
Date Published | 2012 |
ISSN | 1423-0399 |
Keywords | Aged, Aged, 80 and over, Biopsy, Early Detection of Cancer, Equipment Design, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Optical Devices, Phantoms, Imaging, Predictive Value of Tests, Prostate, Prostatic Hyperplasia, Prostatic Neoplasms, Sensitivity and Specificity, Urology |
Abstract | AIM: To develop a new optical device (prostate optical device, POD) for assessment of prostate tissue stiffness and evaluate its sensitivity and specificity in prostate cancer detection.PATIENTS AND METHODS: POD was tested in prostate phantoms and in patients with indications for prostate biopsy. Its sensitivity and specificity were compared to digital rectal examination (DRE) and transrectal ultrasonography (TRUS).RESULTS: POD was able to identify stiffness differences on each prostate phantom. 45 patients were included in the study. Sensitivity of TRUS (40%) was significantly lower to POD (85.7%) and DRE (74.3%) (p = 0.000 and p = 0.003, respectively). There was no statistical difference between POD and DRE (p = 0.221). The combination of POD and DRE showed the highest sensitivity (88.6%), positive predictive value (81.6%), and negative predictive value (42.9%) among all diagnostic tests.CONCLUSIONS: POD identified prostatic stiffness differences with the same sensitivity of DRE performed by an experienced urologist providing an objective indication for prostate biopsy and early prostate cancer detection. |
DOI | 10.1159/000339966 |
Alternate Journal | Urol. Int. |
PubMed ID | 22986226 |