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Δημοσίευση

VDR TaqI is associated with obesity in the Greek population.

TitleVDR TaqI is associated with obesity in the Greek population.
Publication TypeJournal Article
Year of Publication2013
AuthorsVasilopoulos, Y., Sarafidou T., Kotsa K., Papadimitriou M., Goutzelas Y., Stamatis C., Bagiatis V., Tsekmekidou X., Yovos J. G., & Mamuris Z.
JournalGene
Volume512
Issue2
Pagination237-9
Date Published2013 Jan 10
ISSN1879-0038
KeywordsAged, Alleles, Body Mass Index, DNA Restriction Enzymes, Female, Greece, Humans, Male, Middle Aged, Obesity, Polymorphism, Genetic, Prevalence, Proteins, Receptors, Calcitriol, Risk Factors
Abstract

The prevalence of obesity has increased dramatically during the last thirty years in western countries with severe complications for health and economy. Obesity is the outcome of the strong interplay between genetic and environmental factors and is therefore widely expected that the discovery of the many genetic factors underlying the heritable risk of obesity will contribute critically to our basic knowledge of the disease etiopathogenesis and the identification of new targets for therapeutic intervention. The aim of the present study was to assess the genetic contribution of known polymorphisms in two genes that are linked to the pathogenetic mechanism of obesity. Analysis of vitamin D receptor (VDR) TaqI (rs731236; T/C) and fat mass and obesity-associated (FTO) (rs9930506; A/T) polymorphisms in 82 obesity subjects and 102 controls showed significant association for VDR TaqI 'T' allele and obesity (OR: 2.07; 1.123-3.816; P=0.019), contributing to an elevated BMI of 3kg/m(2) per risk allele. No association was observed for the FTO polymorphism. These results further support a role for VDR as risk factor for obesity and suggest its further validation in larger independent populations as well as highlight a target for functional analysis towards therapeutic intervention in obese individuals.

DOI10.1016/j.gene.2012.10.044
Alternate JournalGene
PubMed ID23103831

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