The english version of the website is under development. Wherever text appears in Greek, it means it has not been translated yet.

Δημοσίευση

Screening for coeliac disease in preschool Greek children: the feasibility study of a community-based project.

TitleScreening for coeliac disease in preschool Greek children: the feasibility study of a community-based project.
Publication TypeJournal Article
Year of Publication2013
AuthorsKaragiozoglou-Lampoudi, T., Zellos A., Vlahavas G., Kafritsa Y., Roma E., Papadopoulou A., Fotoulaki M., Karyda S., Xinias I., & Savvidou A.
JournalActa Paediatr
Volume102
Issue7
Pagination749-54
Date Published2013 Jul
ISSN1651-2227
KeywordsCeliac Disease, Child, Child, Preschool, Community-Based Participatory Research, Feasibility Studies, Female, Greece, GTP-Binding Proteins, Humans, Immunoglobulin A, Male, Mass Screening, Pilot Projects, Prevalence, Transglutaminases
Abstract

AIM: Evaluation of the prevalence of coeliac disease (CD) in Greek paediatric population.METHODS: The project consists of two parts: (i) a pilot study of preschool children aged 2-6 years to test the feasibility and diagnostic accuracy of community-based screening and (ii) a CD prevalence study, by random clustered sampling and proportionate stratification of various geographical areas in Greece. Trained nonmedical staff performed a rapid immunochromatographic test to detect IgA antibodies to tTG-IgA and IgA deficiency. Toddlers with positive results were referred to a paediatric gastroenterologist for further assessment with serum anti-tTG IgA and EMA-IgA. Children with positive serum anti-tTG and anti-EMA underwent upper gastrointestinal tract endoscopy and small bowel biopsy and were subsequently in gluten-free diet.RESULTS: In this project participated 1136 toddlers, who were tested at school. The prevalence of positive rapid anti-tTG screening was 1:154, of IgA deficiency 1:120 and of biopsy-proven CD 1:154. The prevalence of CD from this pilot study served as expected prevalence value for sample size calculation for the main prevalence study.CONCLUSION: This protocol using rapid immunochromatographic test for the detection of both IgA deficiency and CD is easy to be performed by nonmedical staff in a community setting, enabling the accurate identification of new CD cases among asymptomatic population.

DOI10.1111/apa.12241
Alternate JournalActa Paediatr.
PubMed ID23600795

Contact

Secretariat of the School of Medicine
 

Connect

School of Medicine's presence in social networks
Follow Us or Connect with us.