Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval.
Title | Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Galli-Tsinopoulou, A., Chatzidimitriou A., Kyrgios I., Rousso I., Varlamis G., & Karavanaki K. |
Journal | J Pediatr Endocrinol Metab |
Volume | 27 |
Issue | 3-4 |
Pagination | 237-43 |
Date Published | 2014 Mar |
ISSN | 2191-0251 |
Keywords | Child, Diabetes Mellitus, Type 1, Electrocardiography, Female, Heart, Humans, Male, Risk Factors, Young Adult |
Abstract | BACKGROUND: QT-wave abnormalities have been detected in type 1 diabetes mellitus (T1DM). Prolongation of the heart rate corrected QT interval (QTc) has been associated with cardiovascular mortality. We evaluated how often QT/QTc abnormalities are present in youth with T1DM and if they are associated with disease parameters.METHODS: Sixty-two T1DM youngsters and equal age- and gender-matched controls were studied. Demographic, anthropometric, and laboratory data were determined. QT was measured on a 12-lead resting electrocardiogram. QTc was calculated using Bazett's formula.RESULTS: T1DM patients had significantly longer QT/QTc than controls, but significance disappeared after adjustment for confounders. Abnormally prolonged QTc≥440 ms was observed six times more frequently in those with T1DM. QT was correlated with age, age at disease onset, but not with glycated hemoglobin or diabetes duration; QTc was only correlated with pubertal stage.CONCLUSIONS: T1DM youths have a sixfold increased risk for QT/QTc prolongation and should have regular follow-up for cardiac autonomic dysfunction. |
DOI | 10.1515/jpem-2013-0193 |
Alternate Journal | J. Pediatr. Endocrinol. Metab. |
PubMed ID | 24127534 |