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Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval.

TitleChildren and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval.
Publication TypeJournal Article
Year of Publication2014
AuthorsGalli-Tsinopoulou, A., Chatzidimitriou A., Kyrgios I., Rousso I., Varlamis G., & Karavanaki K.
JournalJ Pediatr Endocrinol Metab
Volume27
Issue3-4
Pagination237-43
Date Published2014 Mar
ISSN2191-0251
KeywordsChild, Diabetes Mellitus, Type 1, Electrocardiography, Female, Heart, Humans, Male, Risk Factors, Young Adult
Abstract

BACKGROUND: QT-wave abnormalities have been detected in type 1 diabetes mellitus (T1DM). Prolongation of the heart rate corrected QT interval (QTc) has been associated with cardiovascular mortality. We evaluated how often QT/QTc abnormalities are present in youth with T1DM and if they are associated with disease parameters.METHODS: Sixty-two T1DM youngsters and equal age- and gender-matched controls were studied. Demographic, anthropometric, and laboratory data were determined. QT was measured on a 12-lead resting electrocardiogram. QTc was calculated using Bazett's formula.RESULTS: T1DM patients had significantly longer QT/QTc than controls, but significance disappeared after adjustment for confounders. Abnormally prolonged QTc≥440 ms was observed six times more frequently in those with T1DM. QT was correlated with age, age at disease onset, but not with glycated hemoglobin or diabetes duration; QTc was only correlated with pubertal stage.CONCLUSIONS: T1DM youths have a sixfold increased risk for QT/QTc prolongation and should have regular follow-up for cardiac autonomic dysfunction.

DOI10.1515/jpem-2013-0193
Alternate JournalJ. Pediatr. Endocrinol. Metab.
PubMed ID24127534

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