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Galanin in the amniotic fluid and neonatal birth weight: a prospective observational study.

TitleGalanin in the amniotic fluid and neonatal birth weight: a prospective observational study.
Publication TypeJournal Article
Year of Publication2013
AuthorsBili, E., Venetis C., Athanatos D., Tsolakidis D., Assimakopoulos E., & Tarlatzis B.
JournalJ Matern Fetal Neonatal Med
Volume26
Issue13
Pagination1316-20
Date Published2013 Sep
ISSN1476-4954
KeywordsAdult, Amniocentesis, Amniotic Fluid, Birth Weight, Female, Galanin, Gestational Age, Humans, Infant, Newborn, Male, Parity, Pregnancy, Young Adult
Abstract

OBJECTIVE: The aim of the present study was to examine whether an association is present between amniotic fluid (AF) galanin and neonatal birth weight (NBW).DESIGN: Prospective observational study.SETTING: Fetal maternal unit in a tertiary teaching hospital.POPULATION: Fifty women of singleton pregnancy who underwent amniocentesis during the second trimester and delivered after the 37th week of gestation.METHODS: Amniocentesis 18th-19th gestational week for genetic indication with the use of a 22G needle under real-time sonographic guidance and measurement of galanin concentration in the AF.MAIN OUTCOME MEASURES: Association between concentration of AF galanin and NBW at term.RESULTS: Galanin was isolated in all samples of AF (median concentration 19.95 pg/mL; range: 19.0-21.7). A strong linear correlation between AF galanin and NBW was detected (τ = 0.928; p < 0.001). Non-parametric linear regression analysis revealed that galanin concentration could explain 72.1% of the variance in the NBW, when controlling for gestational week at birth and mother's body mass index at delivery.CONCLUSIONS: AF galanin during the second trimester seems to have a strong linear correlation with NBW of term deliveries in singleton pregnancies, even when controlling for important confounders.

DOI10.3109/14767058.2013.783802
Alternate JournalJ. Matern. Fetal. Neonatal. Med.
PubMed ID23480571

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