Galanin in the amniotic fluid and neonatal birth weight: a prospective observational study.
Title | Galanin in the amniotic fluid and neonatal birth weight: a prospective observational study. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Bili, E., Venetis C., Athanatos D., Tsolakidis D., Assimakopoulos E., & Tarlatzis B. |
Journal | J Matern Fetal Neonatal Med |
Volume | 26 |
Issue | 13 |
Pagination | 1316-20 |
Date Published | 2013 Sep |
ISSN | 1476-4954 |
Keywords | Adult, Amniocentesis, Amniotic Fluid, Birth Weight, Female, Galanin, Gestational Age, Humans, Infant, Newborn, Male, Parity, Pregnancy, Young Adult |
Abstract | OBJECTIVE: The aim of the present study was to examine whether an association is present between amniotic fluid (AF) galanin and neonatal birth weight (NBW).DESIGN: Prospective observational study.SETTING: Fetal maternal unit in a tertiary teaching hospital.POPULATION: Fifty women of singleton pregnancy who underwent amniocentesis during the second trimester and delivered after the 37th week of gestation.METHODS: Amniocentesis 18th-19th gestational week for genetic indication with the use of a 22G needle under real-time sonographic guidance and measurement of galanin concentration in the AF.MAIN OUTCOME MEASURES: Association between concentration of AF galanin and NBW at term.RESULTS: Galanin was isolated in all samples of AF (median concentration 19.95 pg/mL; range: 19.0-21.7). A strong linear correlation between AF galanin and NBW was detected (τ = 0.928; p < 0.001). Non-parametric linear regression analysis revealed that galanin concentration could explain 72.1% of the variance in the NBW, when controlling for gestational week at birth and mother's body mass index at delivery.CONCLUSIONS: AF galanin during the second trimester seems to have a strong linear correlation with NBW of term deliveries in singleton pregnancies, even when controlling for important confounders. |
DOI | 10.3109/14767058.2013.783802 |
Alternate Journal | J. Matern. Fetal. Neonatal. Med. |
PubMed ID | 23480571 |