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Oral ulcers in patients with advanced breast cancer receiving everolimus: a case series report on clinical presentation and management.

TitleOral ulcers in patients with advanced breast cancer receiving everolimus: a case series report on clinical presentation and management.
Publication TypeJournal Article
Year of Publication2013
AuthorsNicolatou-Galitis, O., Nikolaidi A., Athanassiadis I., Papadopoulou E., & Sonis S.
JournalOral Surg Oral Med Oral Pathol Oral Radiol
Volume116
Issue2
Paginatione110-6
Date Published2013 Aug
ISSN2212-4411
KeywordsAged, Androstadienes, Anti-Inflammatory Agents, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Carcinoma, Dexamethasone, Everolimus, Female, Follow-Up Studies, Glucocorticoids, Humans, Middle Aged, Oral Ulcer, Prospective Studies, Recurrence, Sirolimus, Stomatitis, Stomatitis, Aphthous, TOR Serine-Threonine Kinases, Treatment Outcome
Abstract

OBJECTIVE: We report the clinical features and management outcomes in 7 patients with everolimus-related stomatitis.STUDY DESIGN: Fifteen women with hormone-receptor-positive advanced breast cancer receiving everolimus combined with exemestane were prospectively evaluated to assess the development of stomatitis. Oral ulcers were diagnosed based on established criteria.RESULTS: Seven patients developed stomatitis (46.6%). All patients were treated with topical dexamethasone solution, while everolimus was temporarily discontinued in 4 patients. Stomatitis resolved within 1-2 weeks. Two of the 4 patients, who had interrupted everolimus, developed recurrent stomatitis following drug resume and everolimus was again discontinued and restarted after 2 weeks. To date, 5 patients receive everolimus in full dose. The 2 patients, who developed recurrent stomatitis, received a reduced dose.CONCLUSIONS: Everolimus-related oral ulcers were frequent and led to dose modifications. Controlled trials, endorsing a consensus in terminology, are needed to evaluate measures on prevention and management of this unique toxicity.

DOI10.1016/j.oooo.2013.02.022
Alternate JournalOral Surg Oral Med Oral Pathol Oral Radiol
PubMed ID23643584

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