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Is there an association between inflammatory bowel diseases and carotid intima-media thickness? Preliminary data.

TitleIs there an association between inflammatory bowel diseases and carotid intima-media thickness? Preliminary data.
Publication TypeJournal Article
Year of Publication2014
AuthorsTheocharidou, E., Gossios T. D., Griva T., Giouleme O., Douma S., Athyros V. G., & Karagiannis A.
JournalAngiology
Volume65
Issue6
Pagination543-50
Date Published2014 Jul
ISSN1940-1574
KeywordsAdolescent, Adult, Age Factors, Body Mass Index, Carotid Intima-Media Thickness, Case-Control Studies, Female, Humans, Inflammatory Bowel Diseases, Male, Middle Aged, Young Adult
Abstract

Inflammation is a predictor of cardiovascular disease (CVD). Thus, inflammatory bowel diseases (IBD) may be associated with CVD. We assessed carotid intima-media thickness (cIMT; an indicator of CVD risk) in 42 patients with IBD, free of CVD or diabetes; 26 with Crohn's disease (CD) and 16 with ulcerative colitis (UC). The cIMT was significantly greater in patients with IBD compared to 42 healthy controls (0.62 ± 0.08 vs 0.52 ± 0.06 mm; P < .0005). The cIMT did not differ between patients with CD and UC or between the different disease activity and treatment groups. Factors associated with cIMT were age, body mass index, and IBD, with the latter making a greater contribution. The IBD is a predictor of cIMT, even when other CVD risk factors are considered. These findings suggest an association between early arterial wall alterations and IBD. Such an association should be proven in larger studies that should assess the incidence of CVD in patients with IBD.

DOI10.1177/0003319713489876
Alternate JournalAngiology
PubMed ID23748978

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