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Short communication: molecular epidemiology of HIV type 1 infection in northern Greece (2009-2010): evidence of a transmission cluster of HIV type 1 subtype A1 drug-resistant strains among men who have sex with men.

TitleShort communication: molecular epidemiology of HIV type 1 infection in northern Greece (2009-2010): evidence of a transmission cluster of HIV type 1 subtype A1 drug-resistant strains among men who have sex with men.
Publication TypeJournal Article
Year of Publication2014
AuthorsAntoniadou, Z-A., Kousiappa I., Skoura L., Pilalas D., Metallidis S., Nicolaidis P., Malisiovas N., & Kostrikis L. G.
JournalAIDS Res Hum Retroviruses
Volume30
Issue3
Pagination225-32
Date Published2014 Mar
ISSN1931-8405
KeywordsAdult, Aged, Cluster Analysis, Disease Transmission, Infectious, Drug Resistance, Viral, Female, Genotype, Greece, HIV Infections, HIV-1, Homosexuality, Male, Humans, Male, Middle Aged, Molecular Epidemiology, Molecular Sequence Data, pol Gene Products, Human Immunodeficiency Virus, Prospective Studies, Sequence Analysis, DNA, Sequence Homology, Young Adult
Abstract

A prospective molecular epidemiology study of HIV-1 infection was conducted in newly diagnosed and antiretroviral-naive patients in Northern Greece between 2009 and 2010 using a predefined enrolling strategy. Phylogenetic trees of the pol sequences obtained in this study with reference sequences indicated that subtypes B and A1 were the most common subtypes present and accounted for 44.9% and 42.9%, respectively, followed by subtype C (3.1%), CRF02_AG (4.1%), CRF04_cpx (2.0%), and subtypes CRF01_01, F1, and G (1.0%). A high rate of clustered transmission of subtype A1-resistant strains to reverse transcriptase (RT) inhibitors was observed among men having sex with men. Indeed, 15 out of 17 study subjects (88.2%) infected with transmitted drug resistance (TDR) strains were implicated in transmission clusters, 10 of whom (66.7%) were men who have sex with men (MSM), and were also infected with subsubtype A1 strains. The main cluster within subtype A1 (I) included eight men reporting having sex with men from Thessaloniki infected with dual-class RT-resistant strains carrying both T215C and Y181C mutations.

DOI10.1089/AID.2013.0166
Alternate JournalAIDS Res. Hum. Retroviruses
PubMed ID24059291
PubMed Central IDPMC3938947

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