Left ventricular systolic and diastolic function in normotensive type 2 diabetic patients with or without autonomic neuropathy: a radionuclide ventriculography study.
Title | Left ventricular systolic and diastolic function in normotensive type 2 diabetic patients with or without autonomic neuropathy: a radionuclide ventriculography study. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Didangelos, T. P., Arsos G., Karamitsos T., Iliadis F., Papageorgiou A., Moralidis E., & Athyros V. |
Journal | Angiology |
Volume | 65 |
Issue | 10 |
Pagination | 877-82 |
Date Published | 2014 Nov |
ISSN | 1940-1574 |
Keywords | Cardiac Output, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Diastole, Female, Heart Rate, Humans, Male, Middle Aged, Patient Selection, Radionuclide Ventriculography, Systole, Ventricular Dysfunction, Left, Ventricular Function, Left |
Abstract | We investigated the relation between diabetic autonomic neuropathy (DAN) and left ventricular (LV) function in 59 patients with type 2 diabetes mellitus (T2DM) free of coronary artery disease (CAD) or hypertension. Diabetic autonomic neuropathy was established by ≥2 abnormal autonomic nervous function tests. Left ventricular systolic and diastolic functions were assessed by resting radionuclide ventriculography. Compared with non-DAN patients (n=24), patients with DAN (n=35) had an increased adjusted atrial contribution to ventricular filling (A/V%, 30.1%±8.2% vs 26.5%±5.1%; P=.031), suggestive of diastolic dysfunction (DD). There were no differences between the 2 groups in peak filling rate, first 1/3 filling fraction, ejection fraction, cardiac output, and cardiac index. Patients with diabetic autonomic neuropathy had an increased heart rate (77.8±6.3 vs 69.3±3.3 bpm; P<.0001) and a higher rest LV workload (10,072±1165 vs 8606±1075 bpm mm Hg; P<.0001). Patients with DAN T2DM without CAD or hypertension have DD, increased A/V index, and a higher LV working load than non-DAN patients. |
DOI | 10.1177/0003319713510966 |
Alternate Journal | Angiology |
PubMed ID | 24265250 |