The english version of the website is under development. Wherever text appears in Greek, it means it has not been translated yet.

Δημοσίευση

Left ventricular systolic and diastolic function in normotensive type 2 diabetic patients with or without autonomic neuropathy: a radionuclide ventriculography study.

TitleLeft ventricular systolic and diastolic function in normotensive type 2 diabetic patients with or without autonomic neuropathy: a radionuclide ventriculography study.
Publication TypeJournal Article
Year of Publication2014
AuthorsDidangelos, T. P., Arsos G., Karamitsos T., Iliadis F., Papageorgiou A., Moralidis E., & Athyros V.
JournalAngiology
Volume65
Issue10
Pagination877-82
Date Published2014 Nov
ISSN1940-1574
KeywordsCardiac Output, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Diastole, Female, Heart Rate, Humans, Male, Middle Aged, Patient Selection, Radionuclide Ventriculography, Systole, Ventricular Dysfunction, Left, Ventricular Function, Left
Abstract

We investigated the relation between diabetic autonomic neuropathy (DAN) and left ventricular (LV) function in 59 patients with type 2 diabetes mellitus (T2DM) free of coronary artery disease (CAD) or hypertension. Diabetic autonomic neuropathy was established by ≥2 abnormal autonomic nervous function tests. Left ventricular systolic and diastolic functions were assessed by resting radionuclide ventriculography. Compared with non-DAN patients (n=24), patients with DAN (n=35) had an increased adjusted atrial contribution to ventricular filling (A/V%, 30.1%±8.2% vs 26.5%±5.1%; P=.031), suggestive of diastolic dysfunction (DD). There were no differences between the 2 groups in peak filling rate, first 1/3 filling fraction, ejection fraction, cardiac output, and cardiac index. Patients with diabetic autonomic neuropathy had an increased heart rate (77.8±6.3 vs 69.3±3.3 bpm; P<.0001) and a higher rest LV workload (10,072±1165 vs 8606±1075 bpm mm Hg; P<.0001). Patients with DAN T2DM without CAD or hypertension have DD, increased A/V index, and a higher LV working load than non-DAN patients.

DOI10.1177/0003319713510966
Alternate JournalAngiology
PubMed ID24265250

Contact

Secretariat of the School of Medicine
 

Connect

School of Medicine's presence in social networks
Follow Us or Connect with us.