The english version of the website of the School of Medicine is under development

Δημοσίευση

Coexpression of IL-6 and TNF-α: prognostic significance on breast cancer outcome.

TitleCoexpression of IL-6 and TNF-α: prognostic significance on breast cancer outcome.
Publication TypeJournal Article
Year of Publication2014
AuthorsTripsianis, G., Papadopoulou E., Anagnostopoulos K., Botaitis S., Katotomichelakis M., Romanidis K., Kontomanolis E., Tentes I., & Kortsaris A.
JournalNeoplasma
Volume61
Issue2
Pagination205-12
Date Published2014
ISSN0028-2685
KeywordsAdult, Aged, Aged, 80 and over, Biomarkers, Tumor, Breast Neoplasms, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Interleukin-6, Middle Aged, Neoplasm Staging, Prognosis, Survival Analysis, Treatment Outcome, Tumor Necrosis Factor-alpha
Abstract

Presented study was conducted to investigate the prognostic significance of the coexpression of serum interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) in breast cancer, by correlating their presence with clinicopathological characteristics indicative of tumor progression and the overall survival of breast cancer patients. One hundred twelve consecutive patients with primary breast cancer were prospectively included and evaluated. Serum concentrations of IL-6 and TNF-a were measured by quantitative sandwich enzyme immunoassay (ELISA). Median split was used to subdivide patients with low or high IL-6 and TNF-a levels. A positive association between the expression of the two cytokines was found. The coexpression of high IL-6 and TNF-α was independently associated with extended lymph node (>3) involvement (aOR, 7.8) and lymphovascular invasion (aOR, 14.1), increasing the prognostic significance of each cytokine separately; it also provided additional prognostic information regarding survival, defining a high-risk subgroup of patients with significantly shorter survival and higher risk of death compared to patients with both cytokines low (aHR, 4.45) and patients with only one cytokine high (aHR, 3.63). Our findings suggest that the coexpression of these two cytokines could be used clinically as a useful tumor marker for the extension and the outcome of the disease.

DOI10.4149/neo_2014_026
Alternate JournalNeoplasma
PubMed ID24299316

Contact

Secretariat of the School of Medicine
 

Connect

Schoole of Medicince presence in social networks
Follow Us or Connect with us.