The english version of the website is under development. Wherever text appears in Greek, it means it has not been translated yet.


Moxifloxacin pharmacokinetics and pleural fluid penetration in patients with pleural effusion.

TitleMoxifloxacin pharmacokinetics and pleural fluid penetration in patients with pleural effusion.
Publication TypeJournal Article
Year of Publication2014
AuthorsChatzika, K., Manika K., Kontou P., Pitsiou G., Papakosta D., Zarogoulidis K., & Kioumis I.
JournalAntimicrob Agents Chemother
Date Published2014
KeywordsAdult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Body Fluids, Female, Fluoroquinolones, Humans, Injections, Intravenous, Male, Middle Aged, Pleural Cavity, Pleural Effusion, Young Adult

The aim of this study was to evaluate the pharmacokinetics and penetration of moxifloxacin (MXF) in patients with various types of pleural effusion. Twelve patients with empyema/parapneumonic effusion (PPE) and 12 patients with malignant pleural effusion were enrolled in the study. A single-dose pharmacokinetic study was performed after intravenous administration of 400 mg MXF. Serial plasma (PL) and pleural fluid (PF) samples were collected during a 24-h time interval after drug administration. The MXF concentration in PL and PF was determined by high-performance liquid chromatography, and main pharmacokinetic parameters were estimated. Penetration of MXF in PF was determined by the ratio of the area under the concentration-time curve from time zero to 24 h (AUC24) in PF (AUC24PF) to the AUC24 in PL. No statistically significant differences in the pharmacokinetics in PL were observed between the two groups, despite the large interindividual variability in the volume of distribution, clearance, and elimination half-life. The maximum concentration in PF (CmaxPF) in patients with empyema/PPE was 2.23±1.31 mg/liter, and it was detected 7.50±2.39 h after the initiation of the infusion. In patients with malignant effusion, CmaxPF was 2.96±1.45 mg/liter, but it was observed significantly earlier, at 3.58±1.38 h (P<0.001). Both groups revealed similar values of AUC24PF (31.83±23.52 versus 32.81±12.66 mg·h/liter). Penetration of MXF into PF was similarly good in both patient groups (1.11±0.74 versus 1.17±0.39). Despite similar plasma pharmacokinetics, patients with empyema/parapneumonic effusion showed a significant delay in achievement of PF maximum MXF levels compared to those with malignant effusion. However, in both groups, the degree of MXF PF penetration and the on-site drug exposure, expressed by AUC24PF, did not differ according to the type of pleural effusion.

Alternate JournalAntimicrob. Agents Chemother.
PubMed ID24323477
PubMed Central IDPMC3957872


Secretariat of the School of Medicine


School of Medicine's presence in social networks
Follow Us or Connect with us.