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Experimentation with inhaled bronchodilators and corticosteroids.

TitleExperimentation with inhaled bronchodilators and corticosteroids.
Publication TypeJournal Article
Year of Publication2014
AuthorsZarogoulidis, P., Porpodis K., Kioumis I., Petridis D., Lampaki S., Spyratos D., Papaiwannou A., Organtzis J., Kontakiotis T., Manika K., Darwiche K., Freitag L., Tsiouda T., Papakosta D., & Zarogoulidis K.
JournalInt J Pharm
Volume461
Issue1-2
Pagination411-8
Date Published2014 Jan 30
ISSN1873-3476
KeywordsAdministration, Inhalation, Aerosols, Bronchodilator Agents, Equipment Design, Glucocorticoids, Nebulizers and Vaporizers, Ultrasonics
Abstract

BACKGROUND: Inhaled bronchodilators and corticosteroids have been used for decades with different production systems.MATERIALS AND METHODS: The following jet-nebulizers: (a) Invacare, (b) Sunmist, (c) Maxineb and ultrasound nebulizers: (a) GIMA, (b) OMRON and (c) EASY NEB II were used as production systems. The jet-nebulizers were used with different residual cups and volume filling, while the ultrasound nebulizers with different volume fillings and face mask versus inlet.RESULTS: Inhalation and ultrasound process detect significant differences between the factors and interactions considered, but each technique follows a specific pattern of magnitude effect. Thus the inhaled mechanism ranks the factor effects in decreasing order: residual cup>drug>nebulizer>loading (2, 3, 4 ml) and also drug>residual cup>nebulizer (loading 8 ml). The ultrasound mechanism orders as follows: nebulizer>drug>loading. In fact, varying micro environmental conditions created during the performance of the devices in both processes alternate the magnitude of factor significance allowing for unique capacities.CONCLUSIONS: PULMICORT, MAXINEB, design cup J and loading 6 ml are the best options for the inhaled process. Optimal combinations are provided by FLIXOTIDE and cup B and also by MAXINEB and cup J. The incorporation of large residual cups suggests one out of six drugs, the SUNMIST nebulizer and design D as the best choices. Ultrasound performance informs for other optimal conditions: ZYLOREN, MAXINEB, 4 ml load and MAXINEB×loading 4 ml.

DOI10.1016/j.ijpharm.2013.12.010
Alternate JournalInt J Pharm
PubMed ID24361267

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