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Serous ovarian cancer signaling pathways.

TitleSerous ovarian cancer signaling pathways.
Publication TypeJournal Article
Year of Publication2014
AuthorsKotsopoulos, I. C., Papanikolaou A., Lambropoulos A. F., Papazisis K. T., Tsolakidis D., Touplikioti P., & Tarlatzis B. C.
JournalInt J Gynecol Cancer
Volume24
Issue3
Pagination410-7
Date Published2014 Mar
ISSN1525-1438
KeywordsCystadenocarcinoma, Serous, Female, Humans, Ovarian Neoplasms, Signal Transduction
Abstract

Ovarian cancer is the most lethal malignancy of the female genital tract, mainly due to the failure of early diagnosis and the limitations posed by the conventional chemotherapies. Current research has focused in the study of cascades of various cellular molecular reactions, known as signaling pathways. In this review article, authors try to describe the current knowledge regarding the signaling pathways that influence multiple cellular processes in serous ovarian cancer and especially the pathogenesis. Thorough understanding of the precise role of these pathways can lead to the development of new and more effective targeted therapies as well as novel biomarkers in ovarian cancer.

DOI10.1097/IGC.0000000000000079
Alternate JournalInt. J. Gynecol. Cancer
PubMed ID24476895

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