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Patterns in the parathyroid response to sodium bicarbonate infusion test in healthy volunteers.

TitlePatterns in the parathyroid response to sodium bicarbonate infusion test in healthy volunteers.
Publication TypeJournal Article
Year of Publication2014
AuthorsPapavramidis, T. S., Anastasiou O. E., Pliakos I., Michalopoulos N., Polyzonis M., Triantafyllopoulou K., Kokaraki G., & Papavramidis S.
JournalBiomed Res Int
Volume2014
Pagination704394
Date Published2014
ISSN2314-6141
KeywordsAdult, Albumins, Calcium, Healthy Volunteers, Humans, Middle Aged, Parathyroid Glands, Parathyroid Hormone, Sodium Bicarbonate, Vitamin D
Abstract

BACKGROUND: The sodium bicarbonate infusion test evaluates the function of the parathyroid glands. The present study aims to evaluate the range of parathyroid response in healthy individuals and the potential influence of various factors.METHODS: Fifty healthy volunteers were subjected to the test. Levels of vitamin D, calcium, albumin, and PTH were measured before infusion. PTH was measured at 3, 5, 10, 30, and 60 minutes after infusion.RESULTS: A curve describing the response of parathyroids to the test was drawn. Twenty percent of the subjects had blunted PTH response. No significant difference was observed between normal and blunted responders concerning age, BMI, baseline PTH, or calcium levels. Nonetheless, there was a significant difference in vitamin D levels (P = 0.024).INTERPRETATION: The test is easy to perform and may be used for everyday screening. It has to be clarified whether our observations are, at least partly, produced due to the presence of individuals with a constitutively blunted response or if low levels of vitamin D decrease the ability of the parathyroids to respond. Whichever the case, PTH response of normal individuals to sodium bicarbonate infusion test is more varied than previously thought and vitamin D levels influence it.

DOI10.1155/2014/704394
Alternate JournalBiomed Res Int
PubMed ID24804234
PubMed Central IDPMC3997070

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