Antibodies against gangliosides in patients with dementia.
| Title | Antibodies against gangliosides in patients with dementia. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Hatzifilippou, E., Koutsouraki E., Costa V. G., & Baloyannis S. J. |
| Journal | Am J Alzheimers Dis Other Demen |
| Volume | 29 |
| Issue | 8 |
| Pagination | 660-6 |
| Date Published | 2014 Dec |
| ISSN | 1938-2731 |
| Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Autoantibodies, Case-Control Studies, Dementia, Enzyme-Linked Immunosorbent Assay, Female, G(M1) Ganglioside, Gangliosides, Humans, Immunoglobulin M, Male, Middle Aged |
| Abstract | BACKGROUND: Increasing evidence suggests that gangliosides act as important mediators in both de- and remyelination. The scope of the present research was to investigate the presence of immunoglobulin (Ig) M antibodies against GM1, GD1b, and GQ1b gangliosides in the sera of patients with dementia and the possible connection with clinical parameters of the disease.METHOD: This research topic demonstrates the investigation of 103 patients with dementia and 60 healthy individuals using enzyme-linked immunosorbent assay for the presence of 3 antiganglioside antibodies in their sera.RESULTS: The authors report a positive connection between IgM anti-GM1 and the age (P = .005) and the severity of dementia (P = .005). Most of the patients who revealed increased IgM anti-GD1b levels had Alzheimer's disease (AD; P = .002).CONCLUSION: This study indicates that elevated IgM anti-GM1 may be connected with the neurodegeneration in older patients with severe dementia and that AD may also be associated with increased IgM anti-GD1b levels. |
| DOI | 10.1177/1533317514534953 |
| Alternate Journal | Am J Alzheimers Dis Other Demen |
| PubMed ID | 24838532 |
