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Non-HLA genes in ankylosing spondylitis: what meta-analyses have shown?

TitleNon-HLA genes in ankylosing spondylitis: what meta-analyses have shown?
Publication TypeJournal Article
Year of Publication2014
AuthorsChatzikyriakidou, A., Voulgari P. V., & Drosos A. A.
JournalClin Exp Rheumatol
Date Published2014 Sep-Oct
KeywordsGenetic Predisposition to Disease, Humans, Meta-Analysis as Topic, Phenotype, Polymorphism, Genetic, Risk Assessment, Risk Factors, Spondylitis, Ankylosing

HLA-B27 association with ankylosing spondylitis (AS) is one of the strongest ever reported in the literature. However, only a small proportion of 5-8% of HLA-B27 positive individuals of the general population develops the disease. In recent years, polymorphisms of many non-HLA genes were reported to be associated with AS. In this review, we summarise the current knowledge of non-HLA genetic factors contributing to AS susceptibility based on meta-analyses in order to overcome the limitations of individual genetic studies e.g. the small samples' sizes, the small samples' origin diversities, and the low statistical power of statistical analyses.

Alternate JournalClin. Exp. Rheumatol.
PubMed ID25068597


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