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Association of brain-derived neurotrophic factor (BDNF) and elongator protein complex 4 (ELP4) polymorphisms with benign epilepsy with centrotemporal spikes in a Greek population.

TitleAssociation of brain-derived neurotrophic factor (BDNF) and elongator protein complex 4 (ELP4) polymorphisms with benign epilepsy with centrotemporal spikes in a Greek population.
Publication TypeJournal Article
Year of Publication2014
AuthorsGkampeta, A., Fidani L., Clarimón J., Kalinderi K., Katopodi T., Zafeiriou D., & Pavlou E.
JournalEpilepsy Res
Volume108
Issue10
Pagination1734-9
Date Published2014 Dec
ISSN1872-6844
KeywordsBrain-Derived Neurotrophic Factor, Case-Control Studies, Child, Child, Preschool, Electroencephalography, Epilepsy, Rolandic, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Greece, Haplotypes, Humans, Male, Nerve Tissue Proteins, Polymorphism, Single Nucleotide
Abstract

PURPOSE: Benign epilepsy with centrotemporal spikes (BECTS) is considered to be the most common childhood epileptic syndrome. Different mutations in genes that control the excitability of neurons have been described. Recent reports on the involvement of the BDNF and ELP4 genes in cell motility, migration, and adhesion raise the possibility that these genes are involved in pathogenesis of BECTS.MATERIALS AND METHODS: We conducted a case-control association study on 60 patients with BECTS and 60 control participants to assess the influence of the BDNF and ELP4 polymorphisms on BECTS. The polymorphisms were detected with a PCR-RFLP method. Moreover, we explored the possible association of these polymorphisms with clinical and electroencephalographic parameters of patients with BECTS.RESULTS: Our results show no difference in BDNF and ELP4 genotype frequencies between patients and controls. Haplotype analysis also revealed no statistical difference.CONCLUSION: The role of BDNF and ELP4 polymorphisms remains controversial.

DOI10.1016/j.eplepsyres.2014.09.005
Alternate JournalEpilepsy Res.
PubMed ID25301525

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