Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit.
Title | Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Tsiatsiou, O., Iosifidis Ε., Katragkou A., Dimou V., Sarafidis K., Karampatakis T., Antachopoulos C., Orfanou A., Tsakris A., Drossou-Agakidou V., & Roilides E. |
Journal | Eur J Pediatr |
Volume | 174 |
Issue | 1 |
Pagination | 65-74 |
Date Published | 2015 Jan |
ISSN | 1432-1076 |
Keywords | Acinetobacter baumannii, Acinetobacter Infections, Anti-Bacterial Agents, beta-Lactam Resistance, beta-Lactamases, Carbapenems, Colistin, Disease Outbreaks, Feces, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Prospective Studies, Thienamycins |
Abstract | UNLABELLED: The investigation and successful management of a monoclonal Acinetobacter baumannii outbreak in a neonatal intensive care unit are described. Upon the first clustered carbapenem-resistant A. baumannii (CRAB) infections, a bundle of actions were taken, including enhanced infection control, active surveillance (weekly stool samples), case-control study, staff education, daily audits and discontinuation of new admissions. Between September and December 2011, eight neonates developed 10 CRAB infections (five blood, four respiratory and one eye). A total of 216 active surveillance cultures were obtained from 96 neonates (43 % had ≥2 samples). During weeks 12, 16 and 17, active surveillance detected 3, 1 and 2 new CRAB acquisitions, respectively. Prevalence of infections/colonizations decreased, and no event occurred after 20th week. A colonized neonate developed CRAB sepsis and died. All CRAB isolates harboured bla OXA-58 and the intrinsic chromosomal bla OXA-51 carbapenemase genes.CONCLUSION: Active surveillance and enhanced infection control measures effectively contained spread of CRAB clone in the neonatal intensive care unit. |
DOI | 10.1007/s00431-014-2365-8 |
Alternate Journal | Eur. J. Pediatr. |
PubMed ID | 24985124 |