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Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade.

TitleDouble- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade.
Publication TypeJournal Article
Year of Publication2015
AuthorsMeletis, G., Chatzidimitriou D., & Malisiovas N.
JournalEur J Clin Microbiol Infect Dis
Volume34
Issue8
Pagination1487-93
Date Published2015 Aug
ISSN1435-4373
KeywordsBacterial Proteins, beta-Lactamases, Cross Infection, Drug Resistance, Multiple, Bacterial, Global Health, Gram-Negative Bacteria, Gram-Negative Bacterial Infections, Humans
Abstract

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative nosocomial pathogens commonly carry one carbapenemase gene conferring resistance to carbapenems and other beta-lactam antibiotics. However, increasing reports show that double-carbapenemase-producing (DCP) and even multi-carbapenemase-producing (MCP) bacteria are emerging in some parts of the world, diminishing further, in some cases, the already limited treatment options. In the present review, the up-to-date reports of DCP and MCP isolates are summarized and concerns regarding their emergence are discussed.

DOI10.1007/s10096-015-2379-9
Alternate JournalEur. J. Clin. Microbiol. Infect. Dis.
PubMed ID25894987

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