IL-17A, IL-22, and IL-23 as Markers of Psoriasis Activity: A Cross-sectional, Hospital-based Study.
| Title | IL-17A, IL-22, and IL-23 as Markers of Psoriasis Activity: A Cross-sectional, Hospital-based Study. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Fotiadou, C., Lazaridou E., Sotiriou E., Gerou S., Kyrgidis A., Vakirlis E., & Ioannides D. |
| Journal | J Cutan Med Surg |
| Volume | 19 |
| Issue | 6 |
| Pagination | 555-60 |
| Date Published | 2015 Nov-Dec |
| ISSN | 1203-4754 |
| Keywords | Adolescent, Adult, Aged, Biomarkers, Case-Control Studies, Cross-Sectional Studies, Female, Flow Cytometry, Humans, Interleukins, Male, Middle Aged, Psoriasis, Sensitivity and Specificity, Tumor Necrosis Factor-alpha, Young Adult |
| Abstract | INTRODUCTION: T-helper 1 (Th1), Th17 cells, and their related cytokines are implicated in psoriasis pathogenesis although the contribution of each group of cytokines in psoriasis activity has not been fully clarified.OBJECTIVES: To investigate whether Th17-related cytokines are associated with psoriasis activity.METHODS: The serum levels of interleukin (IL)-1β, 6, 8, 17Α, 22, 23, and tumor necrosis factor-α (TNFα) were measured with flow cytometry in 35 patients with plaque psoriasis (21 with stable and 14 with active disease) and in 20 healthy controls.RESULTS: Interleukin-6, 8, 17A, 22, 23, and TNFα were significantly elevated in psoriasis patients compared with controls. In the sensitivity analyses, patients with active disease showed significantly increased levels of IL-17A, IL-23, and IL-22 as compared to the group of patients with stable psoriasis.CONCLUSIONS: Our study highlights a possible crucial role of IL-17A, IL-22, and IL-23 in the activity of psoriasis and the early stages of the disease. |
| DOI | 10.1177/1203475415584503 |
| Alternate Journal | J Cutan Med Surg |
| PubMed ID | 25917082 |
