Impact of Helicobacter pylori on multiple sclerosis-related clinically isolated syndrome.
Title | Impact of Helicobacter pylori on multiple sclerosis-related clinically isolated syndrome. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Deretzi, G., Gavalas E., Boziki M., Tsiptsios D., Polyzos S. A., Venizelos I., Zavos C., Koutlas E., Tsiptsios I., Katsinelos P., & Kountouras J. |
Journal | Acta Neurol Scand |
Volume | 133 |
Issue | 4 |
Pagination | 268-75 |
Date Published | 2016 Apr |
ISSN | 1600-0404 |
Abstract | OBJECTIVES: There are no data regarding the relationship between Helicobacter pylori infection (Hp-I) and clinically isolated syndrome (CIS) suggestive of multiple sclerosis. The purpose of this pilot study was to investigate the association between active Hp-I, confirmed by histology, and CIS and to evaluate the impact of Hp eradication on the CIS clinical course.MATERIAL AND METHODS: We conducted a study on 48 patients with CIS and 20 matched controls. At baseline, apart from histology, serum anti-Hp-specific IgG titer, inflammatory mediators, and HLA-A, HLA-B, HLA-DR genetic polymorphisms were estimated. Hp-positive patients received standard triple eradication regimen, and all patients were followed up for 2 years.RESULTS: The prevalence of Hp-I was significantly higher in patients with CIS (43/48, 89.6%) than in control (10/20, 50%) (P < 0.001, OR: 8.6, 95% CI: 2.4-30.8). When compared with controls, patients with CIS also showed significantly higher serum anti-Hp IgG titer and HLA-A26, HLA-A30, and HLA-B57 frequencies. Hp-positive patients also showed higher serum concentrations of inflammatory cytokines and homocysteine. At 2-year clinical endpoint, in the subgroup of CIS patients with successful Hp eradication, the number of patients who presented with a second episode was significantly lower accompanied by significant improvement in mean Expanded Disability Status Scale score.CONCLUSIONS: Hp-I seems more frequent in a Greek CIS cohort and its eradication might delay CIS progression, suggesting a possible link between Hp-I and CIS. |
DOI | 10.1111/ane.12453 |
Alternate Journal | Acta Neurol. Scand. |
PubMed ID | 26079721 |