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4B.08: SERUM LEVELS OF TIMP-1 AND IL-6 ARE ASSOCIATED WITH HYPERTENSION AND ATHEROSCLEROSIS IN PATIENTS WITH EARLY STAGES OF CHRONIC KIDNEY DISEASE AND TYPE 2 DIABETIC NEPHROPATHY.

Title4B.08: SERUM LEVELS OF TIMP-1 AND IL-6 ARE ASSOCIATED WITH HYPERTENSION AND ATHEROSCLEROSIS IN PATIENTS WITH EARLY STAGES OF CHRONIC KIDNEY DISEASE AND TYPE 2 DIABETIC NEPHROPATHY.
Publication TypeJournal Article
Year of Publication2015
AuthorsDimas, G., Iliadis F., Tegos T., Spiroglou S., Kanellos I., Karamouzis I., Savopoulos C., Hatzitolios A., & Grekas D.
JournalJ Hypertens
Volume33 Suppl 1
Paginatione55
Date Published2015 Jun
ISSN1473-5598
Abstract

OBJECTIVE: Tissue inhibitor of metalloproteinase -1 (TIMP-1) has been identified in humans and its expression is regulated during development and tissue remodeling. TIMP-1 overexpression in a mouse model of atherosclerosis showed a lesion reduction. Interleukine-6 (IL-6) is considered to be pro-inflammatory lipocytokine. The aim of the present study was to determine the serum levels of TIMP-1 and IL-6 and to investigate their potential correlation with hypertension, atherosclerotic markers and albuminuria in early stages of type 2 diabetic nephropathy (DN).DESIGN AND METHOD: CKD patients of stages 1 and 2 with type II DN (n = 50) were included. As controls, there were two groups, patients with diabetes type II without CKD (n = 40) and healthy individuals (n = 40). Clearance of creatinine (Clcr) and albumin excretion were examined in the 24 h urine. TIMP-1 and IL-6 levels were measured by an ELISA method. Blood pressure (BP) was taken using a manual sphygmomanometer. Intima media thickness (IMT) of carotid and femoral arteries and atheromatic plaque were evaluated by a high resolution ultrasonography. Statistical analysis was performed with the use of a SPSS system.RESULTS: There was a statistically significant difference between TIMP-1 (400 ± 20, p < 0.0001), IL-6 (4 ± 0.5, p < 0.0001), BP (20 ± 5, p < 0.0001) and IMT (0.3 ± 0.09, p < 0.0001) between patients and controls. There was a statistically significant negative strong correlation between levels of TIMP-1 and IL-6 (r = -0.7, p < 0.0001), such as between TIMP-1 and IMT (r = -0.65, p < 0.0001) in the patient group. There was also a statistically positive correlation between IL-6 and IMT (r = 0.7, p < 0.0001) in the patient group. Further, TIMP-1 and IL-6 levels were independently correlated with IMT and atheromatic plaque.CONCLUSIONS: Our study suggests that serum levels of TIMP-1 and IL-6 might present independent risk factors of blood pressure, atherosclerosis and albuminuria, at least in the early stages of type II diabetic nephropathy to the progression of CKD.

DOI10.1097/01.hjh.0000467492.91729.d5
Alternate JournalJ. Hypertens.
PubMed ID26102854

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