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Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial.

TitleNovasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial.
Publication TypeJournal Article
Year of Publication2015
AuthorsAthanatos, D., Pados G., Venetis C. A., Stamatopoulos P., Rousso D., Tsolakidis D., Stamatopoulos C. P., & Tarlatzis B. C.
JournalClin Exp Obstet Gynecol
Volume42
Issue3
Pagination347-51
Date Published2015
ISSN0390-6663
KeywordsAdult, Amenorrhea, Catheter Ablation, Double-Blind Method, Electric Impedance, Endometrial Ablation Techniques, Female, Humans, Menorrhagia, Metrorrhagia, Microwaves, Middle Aged, Treatment Outcome
Abstract

PURPOSE OF INVESTIGATION: To compare the efficacy and safety of two different second-generation ablation devices, Novasure impedance control system and microwave endometrial ablation (MEA), in cases of abnormal uterine bleeding (AUB).MATERIALS AND METHODS: This is a randomized controlled trial that took place in a single Gynecological Department of a University Hospital. Sixty-six women with dysfunctional uterine bleeding (DUB), unresponsive to medical treatment, were included in the trial. The ratio of women allocated to bipolar radio-frequency ablation or MEA was 1:1. Follow-up assessments were carried out at three and 12 months post-ablation. The present main outcome measure was amenorrhea rates 12-months post-treatment.RESULTS: The rate of amenorrhea at 12-months post-ablation was significantly higher in women treated by Novasure (25/33; 75.8%) as compared to those treated by MEA (8/33; 24.2%) (rate difference: +51.5%, 95% CI: +27.8 to +67.7).CONCLUSION: In women with DUB, endometrial ablation with Novasure bipolar radiofrequency impedance-controlled system is associated with increased rates of amenorrhea at 12-months post-treatment as compared to the MEA method.

Alternate JournalClin Exp Obstet Gynecol
PubMed ID26152008

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