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Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts.

TitleMechanical aberrations in hypetrophic cardiomyopathy: emerging concepts.
Publication TypeJournal Article
Year of Publication2015
AuthorsNtelios, D., Tzimagiorgis G., Efthimiadis G. K., & Karvounis H.
JournalFront Physiol
Volume6
Pagination232
Date Published2015
ISSN1664-042X
Abstract

Hypertrophic cardiomyopathy is the most common monogenic disorder in cardiology. Despite important advances in understanding disease pathogenesis, it is not clear how flaws in individual sarcomere components are responsible for the observed phenotype. The aim of this article is to provide a brief interpretative analysis of some currently proposed pathophysiological mechanisms of hypertrophic cardiomyopathy, with a special emphasis on alterations in the cardiac mechanical properties.

DOI10.3389/fphys.2015.00232
Alternate JournalFront Physiol
PubMed ID26347658
PubMed Central IDPMC4541419

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