Bilateral Eyelid Ptosis, Attributed to Vincristine, Treated Successfully with Pyridoxine and Thiamine in a Child with Acute Lymphoblastic Leukemia.
Title | Bilateral Eyelid Ptosis, Attributed to Vincristine, Treated Successfully with Pyridoxine and Thiamine in a Child with Acute Lymphoblastic Leukemia. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Hatzipantelis, E., Kyriakidis I., Pavlou E., & Pavlidou E. |
Journal | Toxicol Int |
Volume | 22 |
Issue | 1 |
Pagination | 162-4 |
Date Published | 2015 Jan-Apr |
ISSN | 0971-6580 |
Abstract | Vincristine-induced neurotoxicity is an adverse effect commonly seen in pediatric patients treated for cancer. We hereby present a case of a 6-year-old boy with acute lymphoblastic leukemia, who developed bilateral eyelid ptosis 25 days after the last intravenous administration of vincristine (cumulative dose 14.2 mg i.e., 17.75 mg/m(2)). The boy was treated with 5 mg/kg thiamine and with 10 mg/kg pyridoxine. Complete recovery of ptosis was noticed 4 weeks after the initiation of Vitamins B1 and B6 supplementation therapy. |
DOI | 10.4103/0971-6580.172275 |
Alternate Journal | Toxicol Int |
PubMed ID | 26862280 |
PubMed Central ID | PMC4721167 |