The Impact of Methylprednisolone Pulses during Relapses of Multiple Sclerosis on the Kinetics of Anti-Interferon-Beta Antibodies.
| Title | The Impact of Methylprednisolone Pulses during Relapses of Multiple Sclerosis on the Kinetics of Anti-Interferon-Beta Antibodies. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Giantzi, V., Karapanayiotides T., Lagoudaki R., Poulatsidou K-N., Lourbopoulos A., Daniilidis M., Taskos N., Milonas I., & Grigoriadis N. |
| Journal | Eur Neurol |
| Volume | 75 |
| Issue | 1-2 |
| Pagination | 82-8 |
| Date Published | 2016 |
| ISSN | 1421-9913 |
| Keywords | Administration, Intravenous, Adult, Antibodies, Neutralizing, Enzyme-Linked Immunosorbent Assay, Female, Humans, Interferon-beta, Kinetics, Methylprednisolone, Multiple Sclerosis, Neuroprotective Agents |
| Abstract | BACKGROUND/AIMS: We assessed the, hitherto unknown, impact of intravenous methylprednisolone (ivMP) pulses during relapses of multiple sclerosis (MS) on the kinetics of anti-interferon-beta neutralizing antibodies (Nabs) and binding antibodies (Babs).METHODS: Babs (ELISA) and Nabs (antiviral cytopathic effect assay) titers were evaluated before, immediately after and at 1 month following ivMP in 60 MS patients.RESULTS: ivMP reduces Nabs and Babs titers for at least 1 month. Baseline titers determine Nabs and Babs seronegativity at the end of ivMP. Clinical response to ivMP tends to be better in Nabs(+) patients.CONCLUSION: Sampling for Nabs/Babs should be avoided during or shortly after ivMP to avoid transient positive or negative results that may obscure the decision to switch treatment. |
| DOI | 10.1159/000444319 |
| Alternate Journal | Eur. Neurol. |
| PubMed ID | 26867030 |
