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Impact of dialysis requirement on outcomes in tumor lysis syndrome.

TitleImpact of dialysis requirement on outcomes in tumor lysis syndrome.
Publication TypeJournal Article
Year of Publication2017
AuthorsGarimella, P. S., Balakrishnan P., Ammakkanavar N. R., Patel S., Patel A., Konstantinidis I., Annapureddy N., & Nadkarni G. N.
JournalNephrology (Carlton)
Date Published2017 Jan
KeywordsAcute Kidney Injury, Databases, Factual, Female, Hospital Mortality, Humans, Length of Stay, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Patient Discharge, Renal Dialysis, Risk Factors, Time Factors, Treatment Outcome, Tumor Lysis Syndrome, United States

Tumor lysis syndrome (TLS) is a life threatening emergency due to destruction and massive release of intracellular metabolites from cancer cells often resulting in acute kidney injury (AKI), sometimes severe enough to require dialysis (AKI-D). The impact of dialysis requirement in AKI has not been explored. We utilized data from the Nationwide Inpatient Sample and using International Classification of Diseases, 9th Revision, diagnoses codes for TLS, AKI and dialysis, evaluated the incidence, risk factors and impact of AKI-D on mortality, adverse discharge and length of stay (LOS). Survey multivariable logistic regression was used to compute adjusted Odds Ratios (aOR and 95% confidence intervals (CI). An estimated 12% (2,919) of all TLS hospitalizations (n = 22 875) develop AK-D. After adjustment for confounders, AKI-D was associated with greater odds of mortality (aOR 1.98; (95% CI 1.60-2.45)), adverse discharge (aOR 1.63 (95% CI 1.19-2.24)) and longer LOS (19 vs 14.6 days; P < 0.01) compared with those without AKI-D. Further studies to evaluate the association of AKI-D on long-term outcomes in patients with TLS are needed.

Alternate JournalNephrology (Carlton)
PubMed ID27119419


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