Molecular links between Alzheimer's disease and Gastrointestinal microbiota with its-related metabolic syndrome: emphasis on Helicobacter pylori infection involvement.
Τίτλος | Molecular links between Alzheimer's disease and Gastrointestinal microbiota with its-related metabolic syndrome: emphasis on Helicobacter pylori infection involvement. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Katsinelos, T., Doulberis M., Polyzos S. A., Papaefthymiou A., Katsinelos P., & Kountouras J. |
Journal | Curr Mol Med |
Date Published | 2019 Sep 17 |
ISSN | 1875-5666 |
Abstract | Alzheimer's disease (AD) is a neurodegenerative disease and main form of dementia, charac-terized by progressive cognitive decline and detrimental consequences in both personal-family and global level. Within this narrative review, we provide recent molecular aspects of Tau, a microtubule AD-associated protein as well as amyloid beta, involved in AD pathophysi-ology. Moreover, we provide additional emerging data from basic research as well as clinical studies indicating an implicating role of gastrointestinal microbiota (GIM), including Helicobac-ter pylori infection (Hp-I), in AD pathophysiology. Likewise, we identify through a molecular prism the current evidence of AD pathogenesis as well as its linkage with GIM and emphasiz-ing the role of Hp-I. Furthermore, metabolic syndrome, the epidemic of mainly western socie-ties, is also related with alterations of GIM and Hp-I, which might in turn influence in a molecu-lar, immunological and endocrinological way the pathogenesis of AD. All in all, additional large-scale studies are required for the further clarification of AD pathophysiology and its connec-tion with GIM and and Hp-I, so as novel therapies on molecular basis become available. |
DOI | 10.2174/1566524019666190917125917 |
Alternate Journal | Curr. Mol. Med. |
PubMed ID | 31530263 |