Brimonidine 0.2% given two or three times daily versus timolol maleate 0.5% in primary open-angle glaucoma.
Τίτλος | Brimonidine 0.2% given two or three times daily versus timolol maleate 0.5% in primary open-angle glaucoma. |
Publication Type | Journal Article |
Year of Publication | 2001 |
Authors | Konstas, A. G., Stewart W. C., Topouzis F., Tersis I., Holmes K. T., & Stangos N. T. |
Journal | Am J Ophthalmol |
Volume | 131 |
Issue | 6 |
Pagination | 729-33 |
Date Published | 2001 Jun |
ISSN | 0002-9394 |
Λέξεις κλειδιά | Adrenergic alpha-Agonists, Adrenergic beta-Antagonists, Aged, Brimonidine Tartrate, Circadian Rhythm, Cross-Over Studies, Double-Blind Method, Drug Administration Schedule, Female, Glaucoma, Open-Angle, Humans, Intraocular Pressure, Male, Middle Aged, Osmolar Concentration, Prospective Studies, Quinoxalines, Timolol |
Abstract | PURPOSE: To evaluate the efficacy and safety of brimonidine 0.2% two or three times daily versus timolol maleate 0.5% solution twice daily.METHODS: Patients with primary open-angle glaucoma were randomized by Latin square technique to one of the three treatment sequences in this crossover, prospective double-masked trial. Each treatment period consisted of 6 weeks of chronic dosing followed by a diurnal curve for the intraocular pressure measured at 08:00, 10:00, 16:00, 18:00, 20:00, 22:00, and 24:00 hours. Intraocular pressure was measured by applanation tonometry.RESULTS: Thirty patients completed this trial. The average diurnal intraocular pressures in the trial were measured for timolol maleate (17.7 +/- 2.7 mm Hg), brimonidine given three times daily (18.0 +/- 2.2 mm Hg), and brimonidine given twice daily (19.2 +/- 2.4 mm Hg). There was a statistical difference between groups (P <.005). When groups were compared by pairs, three times daily dosing with brimonidine and timolol maleate both reduced the pressure more than twice daily brimonidine at every time point past 10:00 hours and for the diurnal curve (P <.05). In contrast, three times daily brimonidine and timolol maleate were statistically similar for the diurnal pressure, and each time point, except timolol maleate, decreased the pressure more at 16:00 (P =.042). Safety was similar between groups.CONCLUSIONS: This study demonstrated that both timolol maleate twice daily and brimonidine three times daily provide a similar intraocular pressure reduction to each other. Timolol maleate twice daily and brimonidine three times daily provide a greater decrease in pressure in the late afternoon and nighttime hours, compared with brimonidine twice daily. |
DOI | 10.1016/s0002-9394(01)00834-0 |
Alternate Journal | Am J Ophthalmol |
PubMed ID | 11384568 |