The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study.
Τίτλος | The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Panidis, D., Tziomalos K., Koiou E., Kandaraki E. A., Tsourdi E., Delkos D., Kalaitzakis E., & Katsikis I. |
Journal | Reprod Biol Endocrinol |
Volume | 8 |
Pagination | 151 |
Date Published | 2010 |
ISSN | 1477-7827 |
Λέξεις κλειδιά | Acute-Phase Proteins, Adult, Cross-Sectional Studies, Female, Humans, Insulin Resistance, Lipocalins, Obesity, Overweight, Polycystic Ovary Syndrome, Proto-Oncogene Proteins |
Abstract | BACKGROUND: Lipocalin-2 is a novel adipokine that appears to play a role in the development of insulin resistance. Serum lipocalin-2 levels are elevated in obese patients. Obesity and insulin resistance are cardinal characteristics of the polycystic ovary syndrome (PCOS). However, there are limited data on serum lipocalin-2 levels in patients with PCOS. The aim of the present study was to assess serum lipocalin-2 levels in PCOS.METHODS: We studied 200 patients with PCOS and 50 healthy female volunteers.RESULTS: Serum lipocalin-2 levels were slightly higher in women with PCOS compared with controls (65.4 +/- 34.3 vs. 60.3 +/- 26.0 ng/ml, respectively) but this difference did not reach statistical significance. In contrast, lipocalin-2 levels were higher in overweight/obese women with PCOS than in normal weight women with the syndrome (76.2 +/- 37.3 vs. 54.5 +/- 27.2 ng/ml, respectively; p < 0.001). Serum lipocalin-2 levels were also higher in overweight/obese controls compared with normal weight controls (70.1 +/- 24.9 vs. 50.5 +/- 23.7 ng/ml, respectively; p = 0.004). In the total study population (patients with PCOS and controls), lipocalin-2 levels were independently correlated with the body mass index (p < 0.001). In women with PCOS, lipocalin-2 levels were independently correlated with the waist (p < 0.001).CONCLUSIONS: Obesity is associated with elevated serum lipocalin-2 levels. In contrast, PCOS does not appear to affect lipocalin-2 levels. |
DOI | 10.1186/1477-7827-8-151 |
Alternate Journal | Reprod. Biol. Endocrinol. |
PubMed ID | 21143924 |
PubMed Central ID | PMC3004902 |