Epidemiology, risk factors and outcome of Candida parapsilosis bloodstream infection in children.
Τίτλος | Epidemiology, risk factors and outcome of Candida parapsilosis bloodstream infection in children. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Dotis, J., Prasad P. A., Zaoutis T., & Roilides E. |
Journal | Pediatr Infect Dis J |
Volume | 31 |
Issue | 6 |
Pagination | 557-60 |
Date Published | 2012 Jun |
ISSN | 1532-0987 |
Λέξεις κλειδιά | Adolescent, Age Factors, Candida, Candidemia, Child, Child, Preschool, Cohort Studies, Cross Infection, Female, Hospitals, Pediatric, Humans, Infant, Male, Philadelphia, Respiration, Artificial, Retrospective Studies, Risk Factors, Survival Analysis |
Abstract | BACKGROUND: Candida parapsilosis constitutes a common Candida spp. isolated in children with candidemia. Few data exist on risk factors and outcome of candidemia caused by C. parapsilosis in pediatric patients.METHODS: We conducted a retrospective analysis of demographic data, clinical features, therapeutic procedures and outcomes associated with Candida bloodstream infections (BSIs) that occurred at the Children's Hospital of Philadelphia between 1997 and 2009.RESULTS: Among 406 Candida BSIs, Candida albicans accounted for 198 (49%), C. parapsilosis for 99 (24%) and all other species for 109 (27%) episodes. There was no consistent change in the proportion of C. parapsilosis BSIs during the study. C. parapsilosis BSI was more frequent than non-parapsilosis Candida spp. at age ≤2 years as compared with older patients (62% versus 50%, odds ratio = 1.24, 95% confidence interval: 1.03-1.51, P = 0.038). Patients with C. parapsilosis were more likely to be mechanically ventilated within 48 hours of BSI (odds ratio = 1.38, 95% confidence interval: 1.01-1.85, P = 0.047). Presence of a urinary catheter a week before infection was a protective factor for developing candidemia due to C. parapsilosis spp. (P = 0.003). No significant differences were found between the 2 groups in the presence of central intravascular catheters, comorbidities and clinical or surgical procedures, previous administration of immunosuppressive or antifungal agents and mortality.CONCLUSIONS: C. parapsilosis is the second most frequent cause of candidemia after C. albicans. Although it is more frequent at the age of ≤2 years and is more likely associated with mechanical ventilation than other Candida spp., mortality does not significantly differ between those with and without C. parapsilosis candidemia. |
DOI | 10.1097/INF.0b013e31824da7fe |
Alternate Journal | Pediatr. Infect. Dis. J. |
PubMed ID | 22333703 |
PubMed Central ID | PMC3356455 |
Grant List | 1K23AI0629753-01 / AI / NIAID NIH HHS / United States K23 AI062975-01A1 / AI / NIAID NIH HHS / United States |