High-intensity statin therapy and regression of coronary atherosclerosis in patients with diabetes mellitus.
Τίτλος | High-intensity statin therapy and regression of coronary atherosclerosis in patients with diabetes mellitus. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Athyros, V. G., Katsiki N., Karagiannis A., & Mikhailidis D. P. |
Journal | J Diabetes Complications |
Volume | 29 |
Issue | 1 |
Pagination | 142-5 |
Date Published | 2015 Jan-Feb |
ISSN | 1873-460X |
Λέξεις κλειδιά | Adult, Cholesterol, HDL, Cholesterol, LDL, Coronary Artery Disease, Diabetes Mellitus, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Prognosis, Risk Assessment, Severity of Illness Index, Treatment Outcome, Ultrasonography, Interventional |
Abstract | Recommended low-density lipoprotein cholesterol (LDL-C) levels for patients with documented cardiovascular disease (CVD) are <100mg/dL (2.6mmol/l) with further reduction to <70mg/dL (1.8mmol/l) for higher-risk patients. High-intensity statin treatment may halt the progression as well as stabilize and induce regression of coronary atheromatous plaques while lowering CVD event rates. Diabetes mellitus (DM) is a major negative determinant of coronary artery plaque regression during statin therapy. However, regression of coronary atherosclerosis in DM patients is feasible to the same degree as in those without DM when very low LDL-C values (<70mg/dL; 1.8mmol/l) are achieved with high intensity statin treatment. The recent 2013 American College of Cardiology/American Heart Association (ACC/AHA) Guidelines on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults suggest to abandon specific LDL-C treatment targets. This strategy may deprive high risk patients, such as those with DM, from very high intensity statin treatment or drug combinations aiming to achieve very low LDL-C levels in order to reduce clinical events. |
DOI | 10.1016/j.jdiacomp.2014.10.004 |
Alternate Journal | J. Diabetes Complicat. |
PubMed ID | 25456820 |