Serum levels of bone turnover markers following total joint arthroplasty.
| Τίτλος | Serum levels of bone turnover markers following total joint arthroplasty. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Kenanidis, E. I., Potoupnis M. E., Papavasillioul K. A., Sayegh F. E., Petsatodis G. E., & Kapetanos G. A. |
| Journal | J Orthop Surg (Hong Kong) |
| Volume | 18 |
| Issue | 3 |
| Pagination | 290-5 |
| Date Published | 2010 Dec |
| ISSN | 1022-5536 |
| Λέξεις κλειδιά | Aged, Alkaline Phosphatase, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Biological Markers, Bone Remodeling, Female, Follow-Up Studies, Humans, Male, Middle Aged, Osteoarthritis, Hip, Osteoarthritis, Knee, Osteocalcin, Osteoprotegerin, RANK Ligand, Time Factors |
| Abstract | PURPOSE: To evaluate changes in serum levels of bone turnover markers during the first year following a total hip or knee arthroplasty (THA or TKA, respectively).METHODS: 34 women and 13 men (mean age, 68 years) with idiopathic hip or knee osteoarthritis underwent elective THA or TKA. The serum levels of (1) osteoprotegerin, (2) nuclear factor-kappa B ligand (RANKL), (3) osteocalcin, and (4) bone-specific alkaline phosphatase (b-ALP) were determined in each patient on preoperative day 1 and postoperative day 3 and 7, and month 2, 4, 6, 8, 10, and 12.RESULTS: All 4 markers changed significantly over the 12-month period. At month 12, values of all markers did not return to their preoperative levels uniformly. At month 8, the serum levels of osteoprotegerin, osteocalcin, and b-ALP remained higher than their respective preoperative values. The serum levels of RANKL gradually decreased after month 2, rendering this marker a potential index for fixation.CONCLUSIONS: Bone turnover markers change following arthroplasties. Postoperative month 8 seems to be a milestone in the normal course of these markers. |
| Alternate Journal | J Orthop Surg (Hong Kong) |
| PubMed ID | 21187538 |
