Investigational parathyroid hormone receptor analogs for the treatment of osteoporosis.
Title | Investigational parathyroid hormone receptor analogs for the treatment of osteoporosis. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Polyzos, S. A., Makras P., Efstathiadou Z., & Anastasilakis A. D. |
Journal | Expert Opin Investig Drugs |
Volume | 24 |
Issue | 2 |
Pagination | 145-57 |
Date Published | 2015 Feb |
ISSN | 1744-7658 |
Keywords | Animals, Arrestins, beta-Arrestins, Bone Remodeling, Bone Resorption, Drug Design, Humans, Osteoporosis, Parathyroid Hormone, Parathyroid Hormone-Related Protein, Receptor, Parathyroid Hormone, Type 1, Signal Transduction |
Abstract | INTRODUCTION: Intermittent parathyroid hormone (PTH) administration, acting through multiple signaling pathways, exerts an osteoanabolic effect on the skeleton that surpasses the effect of other antiosteoporotic agents. However, its efficacy is limited by the coupling effect and relatively common adverse events. Thus, the development of more sophisticated PTH receptor analogs seems imperative. |
DOI | 10.1517/13543784.2015.973021 |
Alternate Journal | Expert Opin Investig Drugs |
PubMed ID | 25316089 |