Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12-q13.1 between PLCG1 and D20S17.
| Title | Human hepatocyte nuclear factor-4 (hHNF-4) gene maps to 20q12-q13.1 between PLCG1 and D20S17. |
| Publication Type | Journal Article |
| Year of Publication | 1997 |
| Authors | Argyrokastritis, A., Kamakari S., Kapsetaki M., Kritis A., Talianidis I., & Moschonas N. K. |
| Journal | Hum Genet |
| Volume | 99 |
| Issue | 2 |
| Pagination | 233-6 |
| Date Published | 1997 Feb |
| ISSN | 0340-6717 |
| Keywords | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chromosome Mapping, Chromosomes, Human, Pair 20, DNA-Binding Proteins, Genetic Linkage, Genetic Markers, Hepatocyte Nuclear Factor 4, Humans, In Situ Hybridization, Fluorescence, Isoenzymes, Phospholipase C gamma, Phosphoproteins, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Transcription Factors, Type C Phospholipases |
| Abstract | Human hepatocyte nuclear factor 4 (hHNF-4) is a member of the nuclear hormone receptor superfamily and an important transcription factor and developmental regulator of liver-specific genes. Distinct hHNF-4 cDNAs corresponding to various HNF-4 isoforms have been recently characterised. Three cDNAs, hHNF-4A, B and C, are considered splice variants of a single hHNF-4 gene. We have mapped hHNF-4 to 20q12-q13.1 between PLCG1 and D20S17 by genetic linkage analysis, taking advantage of an adjacent PstI restriction fragment length polymorphism, (RFLP), and by fluorescence in situ hybridisation. hHFN-4 maps to chromosome 20 in a region syntenic with mouse chromosome 2 where the hnf-4 homologue has been assigned. |
| DOI | 10.1007/s004390050345 |
| Alternate Journal | Hum Genet |
| PubMed ID | 9048927 |
