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Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature.

TitleManagement of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature.
Publication TypeJournal Article
Year of Publication2019
AuthorsKosmidis, C., Sapalidis K., Tsakalidis A., Atmatzidis S., Michalopoulos N., Koimtzis G., Karayannopoulou G., Lypiridou S., Varsamis N., Kouklakis G., Baka S., Zarogoulidis P., & Kesisoglou I.
JournalInt J Gen Med
Volume12
Pagination121-124
Date Published2019
ISSN1178-7074
Abstract

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. However, rectal GISTs represent only 5% of this category. We report a case of a rectal GIST treated with local excision after neoadjuvant therapy.
Case presentation: A 41-year-old male patient presented with anal bleeding. Colonoscopy revealed a mass located 5 cm from the anal verge. Histological examination showed a GIST with immunohistochemical positivity for CD117 and CD34. Transanal local excision was performed after neoadjuvant therapy.
Conclusion: Neoadjuvant immunotherapy for GISTs with unfavorable localization may facilitate local excision and avoid complications of more demanding operations.
DOI10.2147/IJGM.S193988
Alternate JournalInt J Gen Med
PubMed ID30881087
PubMed Central IDPMC6402437

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