A meta-analysis of nevus-associated melanoma: Prevalence and practical implications.
Title | A meta-analysis of nevus-associated melanoma: Prevalence and practical implications. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Pampena, R., Kyrgidis A., Lallas A., Moscarella E., Argenziano G., & Longo C. |
Journal | J Am Acad Dermatol |
Volume | 77 |
Issue | 5 |
Pagination | 938-945.e4 |
Date Published | 2017 Nov |
ISSN | 1097-6787 |
Keywords | Adult, Aged, Cell Transformation, Neoplastic, Dysplastic Nevus Syndrome, Female, Humans, Male, Melanoma, Middle Aged, Precancerous Conditions, Prevalence, Prognosis, Risk Assessment, Skin Neoplasms |
Abstract | The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case-control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0.29-0.44; P < .001; I = 99%); nevus-associated melanomas had a lower mean Breslow thickness than de novo melanomas (mean difference -0.39 mm; 95% CI -0.60 to -0.18; P = .0003; I = 66%). No significant differences were noted regarding the association of nevus-associated melanomas with nondysplastic nevi or dysplastic nevi (risk ratio 0.77, 95% CI 0.49-1.20; P = .24; I = 98%). |
DOI | 10.1016/j.jaad.2017.06.149 |
Alternate Journal | J Am Acad Dermatol |
PubMed ID | 28864306 |