Intravenous albumin administration for the prevention of severe ovarian hyperstimulation syndrome: a systematic review and metaanalysis.
Title | Intravenous albumin administration for the prevention of severe ovarian hyperstimulation syndrome: a systematic review and metaanalysis. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Venetis, C. A., Kolibianakis E. M., Toulis K. A., Goulis D. G., Papadimas I., & Tarlatzis B. C. |
Journal | Fertil Steril |
Volume | 95 |
Issue | 1 |
Pagination | 188-96, 196.e1-3 |
Date Published | 2011 Jan |
ISSN | 1556-5653 |
Keywords | Albumins, Female, Humans, Injections, Intravenous, Ovarian Hyperstimulation Syndrome, Ovulation Induction, Pregnancy, Randomized Controlled Trials as Topic, Risk Factors |
Abstract | OBJECTIVE: To reappraise the currently available evidence, providing the answer to the following question: does intravenous albumin administration reduce the risk of severe ovarian hyperstimulation syndrome (OHSS) occurrence following ovarian stimulation with gonadotrophins and GnRH analogues for IVF in high-risk patients?DESIGN: Systematic review and metaanalysis.SETTING: University-based hospital.INTERVENTION(S): Intravenous albumin administration in high-risk patients for prevention of severe OHSS occurrence.MAIN OUTCOME MEASURE(S): Severe OHSS occurrence.RESULT(S): Eight eligible randomized controlled trials were identified (n=1,199 patients) that offered data for statistical pooling. No statistically significant difference in the occurrence of severe OHSS in patients who received intravenous albumin (n=595) and those who did not (n=604; odds ratio [OR], 0.80; 95% confidence interval [CI], 0.52-1.22) was detected. Moreover, no statistically significant differences were present regarding the probability of pregnancy (OR, 0.83; 95% CI, 0.64-1.07) and first trimester pregnancy loss (OR, 1.44; 95% CI, 0.73-2.85) between patients who received intravenous albumin and those who did not.CONCLUSION(S): Based on the currently best available evidence, intravenous albumin administration in high-risk patients does not appear to reduce the occurrence of severe OHSS. This finding should be considered when implementing strategies for severe OHSS prevention. |
DOI | 10.1016/j.fertnstert.2010.05.026 |
Alternate Journal | Fertil. Steril. |
PubMed ID | 20579987 |