Selenomethionine treatment in patients with autoimmune thyroiditis: a prospective, quasi-randomised trial.
Title | Selenomethionine treatment in patients with autoimmune thyroiditis: a prospective, quasi-randomised trial. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Anastasilakis, A. D., Toulis K. A., Nisianakis P., Goulis D. G., Kampas L., Valeri R-M., Oikonomou D., Tzellos T. G., & Delaroudis S. |
Journal | Int J Clin Pract |
Volume | 66 |
Issue | 4 |
Pagination | 378-83 |
Date Published | 2012 Apr |
ISSN | 1742-1241 |
Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Autoantibodies, Female, Hashimoto Disease, Humans, Iodide Peroxidase, Male, Middle Aged, Prospective Studies, Selenomethionine, Thyroglobulin, Treatment Outcome, Young Adult |
Abstract | AIMS: To test whether selenium administration affects autoantibodies to thyroid peroxidase (anti-TPO) and thyroglobulin (anti-TG) titres in chronic autoimmune (Hashimoto's - HT) thyroiditis.METHODS: A prospective, open-label, quasi-randomised study in 86 HT patients (n = 86) assigned to either selenomethionine (Seme) 200μg daily for 3 months (Se3, n = 15) or 6 months (Se6, n = 46) or placebo (Control, n = 25). Serum Se, anti-TPO, anti-TG and thyroid hormones were measured in all patients at baseline, 3 and 6 months. A subgroup of 18 patients (twelve on Se6 and six controls) were subjected in thyroid fine-needle biopsy at baseline and 6 months to detect changes in lymphocyte infiltration.RESULTS: No significant difference in anti-TPO levels was recorded after 3 (p = 0.88) or 6 months (p = 0.62) on Seme. Anti-TG levels decreased both at 3 months (p = 0.001) and 6 months (p = 0.001). No significant changes in thyroid stimulating hormone, free thyroxine and free triiodothyronine levels or in the lymphocytes' number in thyroid cytology specimens were detected. Age, gender, duration of disease, baseline anti-TPO levels and per cent change in Se levels could not predict the response of anti-TPO levels to Seme administration.CONCLUSION: Our data suggest that Seme administration in pharmacological doses for a period of 6 months seems to have no significant effect on serum thyroid auto-antibodies' levels or lymphocyte infiltration of the thyroid gland. |
DOI | 10.1111/j.1742-1241.2011.02879.x |
Alternate Journal | Int. J. Clin. Pract. |
PubMed ID | 22356267 |