T regulatory cells: a promising new target in atherosclerosis.
Title | T regulatory cells: a promising new target in atherosclerosis. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Tselios, K., Sarantopoulos A., Gkougkourelas I., & Boura P. |
Journal | Crit Rev Immunol |
Volume | 34 |
Issue | 5 |
Pagination | 389-97 |
Date Published | 2014 |
ISSN | 1040-8401 |
Keywords | Animals, Arteries, Atherosclerosis, Humans, Immunosuppression, Inflammation, T-Lymphocytes, Regulatory |
Abstract | T regulatory cells (Tregs) comprise the cardinal mechanism of peripheral immune tolerance by modulating the function of virtually each immune cell. Given that atherosclerosis is a chronic inflammation of the arterial wall, certain components of the immune system have been proven to have a central role in its pathogenesis. Consequently, various clinical and experimental studies have been conducted to elucidate the role of Tregs in suppressing this immune-mediated inflammation. In this review, current experimental and clinical knowledge on the role of Tregs in the atherogenic process is presented after a short introduction to their generation and function. Based on these data, Treg-targeted therapeutic approaches are discussed in regard to their potential for clinical application. |
Alternate Journal | Crit. Rev. Immunol. |
PubMed ID | 25404046 |