Pharmacokinetics of Daptomycin in Critically Ill Pediatric Patients.
Title | Pharmacokinetics of Daptomycin in Critically Ill Pediatric Patients. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Antachopoulos, C., Ilia S., Kadiltzoglou P., Baira E., Dokoumetzidis A., Gikas E., Volakli E., Sdougka M., Briassoulis G., & Roilides E. |
Journal | Antimicrob Agents Chemother |
Volume | 62 |
Issue | 6 |
Date Published | 2018 Jun |
ISSN | 1098-6596 |
Abstract | The pharmacokinetics of daptomycin (10 mg/kg once daily) was studied in 4 critically ill pediatric patients aged 8 to 14 yrs. The area under the concentration-time curve from time zero to infinity (AUC) of plasma concentrations on day 1 ranged between 123.8 to 663.9 μg · h/ml, with lower values observed in septic and burn patients; clearance ranged from 15.1 to 80.7 ml/h/kg. Higher-than-recommended doses of daptomycin may be needed in septic children to ensure optimal drug exposure. Interpatient variability may suggest a role for therapeutic drug monitoring. |
DOI | 10.1128/AAC.02462-17 |
Alternate Journal | Antimicrob. Agents Chemother. |
PubMed ID | 29610198 |
PubMed Central ID | PMC5971567 |