Tachyphylaxis to the Sedative Action of Mirtazapine.
| Title | Tachyphylaxis to the Sedative Action of Mirtazapine. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Papazisis, G., Siafis S., & Tzachanis D. |
| Journal | Am J Case Rep |
| Volume | 19 |
| Pagination | 410-412 |
| Date Published | 2018 Apr 07 |
| ISSN | 1941-5923 |
| Keywords | Adult, Antidepressive Agents, Tricyclic, Conscious Sedation, Depression, Dose-Response Relationship, Drug, Female, Humans, Mianserin, Mirtazapine, Tachyphylaxis |
| Abstract | BACKGROUND The pharmacological term tachyphylaxis is used to describe rapidly occurring response desensitization, a situation where the biological response to a given drug dose diminishes when it is given continuously. This pharmacological phenomenon is well observed in some drug categories such as ephedrine, nitrates, beta blockers and H2 antagonists. Mirtazapine is a widely-used antidepressant with a multimodal mechanism of action. CASE REPORT In the present case, we report rapid onset and consistent tachyphylaxis regarding the sedative action of mirtazapine in a 30-year-old female. CONCLUSIONS To our knowledge this is the first reported case of rapid onset and consistent tachyphylaxis to the sedative effect of mirtazapine confirming the complexity of the pharmacological profile of the drug. |
| DOI | 10.12659/ajcr.908412 |
| Alternate Journal | Am J Case Rep |
| PubMed ID | 29626184 |
| PubMed Central ID | PMC5907691 |
