Immunohistochemical evidence for hepatic progenitor cells in liver diseases.
Title | Immunohistochemical evidence for hepatic progenitor cells in liver diseases. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Tan, J., Hytiroglou P., Wieczorek R., Park Y. Nyun, Thung S. N., Arias B., & Theise N. D. |
Journal | Liver |
Volume | 22 |
Issue | 5 |
Pagination | 365-73 |
Date Published | 2002 Oct |
ISSN | 0106-9543 |
Keywords | alpha-Fetoproteins, Antibodies, Monoclonal, Bile Ducts, Intrahepatic, Biomarkers, Hepatocytes, Humans, Immunoenzyme Techniques, Keratins, Liver Diseases, Stem Cells |
Abstract | BACKGROUND/AIM: Proliferative bile ductular reactions occur in a variety of liver diseases in humans. It is a matter of debate whether such reactions result from progenitor cell proliferation with biliary and hepatocytic differentiation, versus biliary metaplasia of damaged hepatocytes. We investigated bile ductular reactions in liver diseases, paying particular attention to the presence of cells with intermediate (hepatocytic/biliary) features (oval-like cells). |
DOI | 10.1034/j.1600-0676.2002.01622.x |
Alternate Journal | Liver |
PubMed ID | 12390471 |