Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease.
| Title | Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease. |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Fidani, L., Goulas A., Mirtsou V., Petersen R. C., Tangalos E., Crook R., & Hardy J. |
| Journal | Neurosci Lett |
| Volume | 323 |
| Issue | 1 |
| Pagination | 81-3 |
| Date Published | 2002 Apr 19 |
| ISSN | 0304-3940 |
| Keywords | Age of Onset, Aged, Alzheimer Disease, Apolipoproteins E, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Interleukin-1, Odds Ratio, Polymerase Chain Reaction, Polymorphism, Genetic, Risk Factors |
| Abstract | Over the past few years, association studies have proposed a number of potential genetic risk factors for Alzheimer's disease (AD). With the exception of the varepsilon4 allele of the apolipoprotein E gene, whose association with the late onset type of AD (LOAD) has been confirmed, the relative significance of most of these associations is still in question. A polymorphism in the interleukin-1A gene (IL-1A2) has been suggested as a risk factor for the early onset as well as for LOAD. In this study, the distribution of IL-1A alleles was examined in a cohort of predominantly LOAD patients and in control individuals. No significant difference was detected in genotype or allele frequencies (odds ratios of 0.929 and 0.743, respectively; P>0.5). We conclude that IL-1A genotype is not a major risk factor for LOAD. |
| DOI | 10.1016/s0304-3940(02)00114-3 |
| Alternate Journal | Neurosci Lett |
| PubMed ID | 11911995 |
