Abdominal aortic aneurysm: a review of the genetic basis.
| Title | Abdominal aortic aneurysm: a review of the genetic basis. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Saratzis, A., Abbas A. A., Kiskinis D., Melas N., Saratzis N., & Kitas G. D. |
| Journal | Angiology |
| Volume | 62 |
| Issue | 1 |
| Pagination | 18-32 |
| Date Published | 2011 Jan |
| ISSN | 1940-1574 |
| Keywords | Aortic Aneurysm, Abdominal, HLA Antigens, Humans, Interleukins, Matrix Metalloproteinases, Peptidyl-Dipeptidase A, Tissue Inhibitor of Metalloproteinases |
| Abstract | BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex disease with a largely unknown pathophysiological background and a strong genetic component. Various studies have tried to link specific genetic variants with AAA.METHODS: Systematic review of the literature (1947-2009).RESULTS: A total of 249 studies were identified, 89 of which were eventually deemed relevant to this review. Genetic variants (polymorphisms) in a wide variety of genes, most of which encode proteolytic enzymes and inflammatory molecules, have been associated with AAA development and progression.CONCLUSION: The genetic basis of AAA remains unknown, and most results from ''candidate-gene'' association studies are contradictory. Further analyses in appropriately powered studies in large, phenotypically well-characterized populations, including genome-wide association studies, are necessary to elucidate the exact genetic contribution to the pathophysiology of AAA. |
| DOI | 10.1177/0003319710373092 |
| Alternate Journal | Angiology |
| PubMed ID | 20566578 |
