N-Acetylcysteine: more than preventing contrast-induced nephropathy in uremic patients-focus on the antioxidant and anti-inflammatory properties.
Title | N-Acetylcysteine: more than preventing contrast-induced nephropathy in uremic patients-focus on the antioxidant and anti-inflammatory properties. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Cepaityte, D., Leivaditis K., Varouktsi G., Roumeliotis A., Roumeliotis S., & Liakopoulos V. |
Journal | Int Urol Nephrol |
Volume | 55 |
Issue | 6 |
Pagination | 1481-1492 |
Date Published | 2023 Jun |
ISSN | 1573-2584 |
Keywords | Acetylcysteine, Anti-Inflammatory Agents, Antioxidants, Humans, Kidney Failure, Chronic, Oxidative Stress, Reactive Oxygen Species, Renal Insufficiency, Chronic |
Abstract | Oxidative stress (OS) has been recognized as a pathophysiologic mechanism underlying the development and progression of chronic kidney disease (CKD). OS, which results from the disturbance of balance among pro-oxidants and antioxidants favoring the pro-oxidants, is present even in early CKD and increases progressively along with deterioration of kidney function to end-stage kidney disease (ESKD). In ESKD, OS is further exacerbated mainly due to dialysis procedures per se and predisposes to increased cardiovascular morbidity and mortality. Therefore, since OS plays a pivotal role in the pathogenesis and progression of atherosclerosis in uremic patients, several strategies aiming to ameliorate OS in these patients have been proposed. Among those, N-acetylcysteine (NAC), a thiol-containing antioxidant agent, has attracted special attention due to its pleiotropic functions and beneficial effect in various OS-related entities including paracetamol overdose and prevention of contrast-induced nephropathy. In this review, we present the currently available literature on the antioxidant and anti-inflammatory properties of NAC in CKD, including hemodialysis and peritoneal dialysis. |
DOI | 10.1007/s11255-022-03455-3 |
Alternate Journal | Int Urol Nephrol |
PubMed ID | 36593372 |
PubMed Central ID | PMC10185578 |