Microarray analysis of NF-kappaB signaling pathways in PBMC of mice infected by Trichinella spiralis.
| Title | Microarray analysis of NF-kappaB signaling pathways in PBMC of mice infected by Trichinella spiralis. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Symeonidou, I., Pappa S., Kourelis A., Anogeianaki A., Frydas I., Karagouni E., & Hatzistilianou M. |
| Journal | Int J Immunopathol Pharmacol |
| Volume | 23 |
| Issue | 3 |
| Pagination | 821-31 |
| Date Published | 2010 Jul-Sep |
| ISSN | 0394-6320 |
| Keywords | Animals, Data Interpretation, Statistical, DNA, Complementary, Mice, Mice, Inbred BALB C, Microarray Analysis, Monocytes, NF-kappa B, Protein Array Analysis, RNA, Signal Transduction, Trichinella spiralis, Trichinellosis |
| Abstract | The NF-kappaΒ pathway gene expression profiles were compared between 10, 20 and 39 days after Trichinella spiralis experimental infection in BALB/c mice. Out of 128 genes, 19 (14.8%) genes were present in non-infected and post-infected mice. The expression of 7 (36.8%) genes was downregulated 10 and 20 days post-infection while 3 (15.8%) genes were upregulated 39 days post-infection. The present study lists the candidate genes of the NF-kappaB signaling pathway that were commonly and differentially expressed between the specific points of T. spiralis infection, thus suggesting that these genes need to be further investigated to reveal the mechanism of the T. spiralis modulation of the NF-kappaB signaling pathways. |
| Alternate Journal | Int J Immunopathol Pharmacol |
| PubMed ID | 20943053 |
