Treatment of non-healing wounds with autologous bone marrow cells, platelets, fibrin glue and collagen matrix.
| Title | Treatment of non-healing wounds with autologous bone marrow cells, platelets, fibrin glue and collagen matrix. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Ravari, H., Hamidi-Almadari D., Salimifar M., Bonakdaran S., Parizadeh M. Reza, & Koliakos G. |
| Journal | Cytotherapy |
| Volume | 13 |
| Issue | 6 |
| Pagination | 705-11 |
| Date Published | 2011 Jul |
| ISSN | 1477-2566 |
| Keywords | Aged, Blood Platelets, Bone Marrow Cells, Bone Marrow Transplantation, Collagen, Female, Fibrin Tissue Adhesive, Humans, Male, Middle Aged, Transplantation, Autologous, Wound Healing |
| Abstract | BACKGROUND AIMS: Recalcitrant diabetic wounds are not responsive to the most common treatments. Bone marrow-derived stem cell transplantation is used for the healing of chronic lower extremity wounds.METHODS: We report on the treatment of eight patients with aggressive, refractory diabetic wounds. The marrow-derived cells were injected/applied topically into the wound along with platelets, fibrin glue and bone marrow-impregnated collagen matrix.RESULTS: Four weeks after treatment, the wound was completely closed in three patients and significantly reduced in the remaining five patients.CONCLUSIONS: Our study suggests that the combination of the components mentioned can be used safely in order to synergize the effect of chronic wound healing. |
| DOI | 10.3109/14653249.2011.553594 |
| Alternate Journal | Cytotherapy |
| PubMed ID | 21284564 |
