Short-, mid-, and long-term benefits of peri-procedural high-intensity statin administration in patients undergoing percutaneous coronary intervention.
Title | Short-, mid-, and long-term benefits of peri-procedural high-intensity statin administration in patients undergoing percutaneous coronary intervention. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Athyros, V. G., Katsiki N., Karagiannis A., & Mikhailidis D. P. |
Journal | Curr Med Res Opin |
Volume | 31 |
Issue | 2 |
Pagination | 191-5 |
Date Published | 2015 Feb |
ISSN | 1473-4877 |
Keywords | Aged, Chemoprevention, Contrast Media, Coronary Artery Disease, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Kidney Diseases, Middle Aged, Percutaneous Coronary Intervention, Perioperative Period |
Abstract | Administration of high intensity statins prior to percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) or stable coronary artery disease has been shown to reduce short-, mid-, and long-term cardiovascular disease (CVD) morbidity and mortality as well as overall mortality compared with lower intensity statins or no statin treatment. The mechanisms involved are probably related to the pleiotropic effects of statins. Improved endothelial function, reduced low grade inflammation and decreased thrombotic diathesis might reduce cardiac injury, diffuse cardiac necrosis, myocardial infarction and no-reflow phenomenon. A decreased risk of contrast-induced nephropathy (CIN) post-PCI might be an extracardiac mechanism that contributes to the reduction in all cause and CVD mortality. These results support the need for the administration of statins before PCI. |
DOI | 10.1185/03007995.2014.954666 |
Alternate Journal | Curr Med Res Opin |
PubMed ID | 25170586 |