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Relative adrenal insufficiency in cirrhotic patients.

TitleRelative adrenal insufficiency in cirrhotic patients.
Publication TypeJournal Article
Year of Publication2015
AuthorsAnastasiadis, S. N., Giouleme O. I., Germanidis G. S., & Vasiliadis T. G.
JournalClin Med Insights Gastroenterol
Date Published2015

Relative adrenal insufficiency (RAI) was demonstrated in patients with cirrhosis and liver failure. A relationship appears to exist between the severity of the liver disease and the presence of RAI. Neither the mechanism nor the exact prevalence of RAI is fully understood. There is though a hypothesis that low high-density lipoprotein (HDL) levels in this group of patients may be responsible for the insufficiency of cortisol. Several questions also arise about the way and the kind of cortisol (total cortisol, free cortisol, or even salivary cortisol) that should be measured. The presence of RAI in patients with cirrhosis is unquestionable, but still several studies should come up in order to properly define it and fully understand it.

Alternate JournalClin Med Insights Gastroenterol
PubMed ID25780347
PubMed Central IDPMC4348066


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